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September 1940


Arch Otolaryngol. 1940;32(3):600-608. doi:10.1001/archotol.1940.00660020604020

Pituitary Dwarfism with Atrophic Rhinitis.Dr. Noah Fabricant and Dr. Pat Bronstein.  Children exhibiting sexual infantilism and defective growth (Lorain-Lévi dwarfs) may be normal at birth and develop adequately until some time in childhood, when growth either ceases or becomes retarded. No special organs are involved. The proportions are those of a normal child. The genital retardation is probably not in excess of the retardation of physical development, and the secondary sexual characteristics are markedly delayed or absent. The mentality may be normal, although the behavior is often immature.No gross evidence of dystrophy of the bones or joints exists, although chondro-epiphysial changes, poorly outlined osseous centers with decreased bone density,have been described. The ossification centers usually appear at the normal time, whereas delay in epiphysial closure is a consistently positive finding. The basal metabolic rate may be normal, but some question exists whether there is a coexistent mild hypothyroidism which

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