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Article
November 1940

PREPARATION OF A PHYSIOLOGIC SOLUTION FOR NASOSINAL TREATMENT

Author Affiliations

OAKLAND, CALIF.

Arch Otolaryngol. 1940;32(5):959-961. doi:10.1001/archotol.1940.00660020966016
Abstract

Ventilation of the nose and sinuses by vasoconstriction alone has become a recognized and widely used method of treatment. For acute and subacute infections it appears to be physiologically justified. To those convinced of its usefulness the following formula is recommended:

  1. Water + ephedrine sulfate to 1 per cent + sodium chloride to 0.68 per cent.

  2. Boil.

  3. Keep in boiled, screw-capped bottles.

Either distilled or tap water may be used. If distilled water is used the solution will need to be alkalinized and buffered at or near the physiologic pH, 7.6; if tap water, the pH may or may not need adjustment. The use of tap water was suggested by Dr. Clifford Sweet1 several years ago. It has proved to be exceedingly advantageous. Natural drinking water usually is alkaline, and the alkalinity is reduced somewhat by the addition of ephedrine. For example, in the San Francisco Bay area the use of

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