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December 1940


Author Affiliations

From the Department of Otolaryngology, Duke University Hospital and Medical School.

Arch Otolaryngol. 1940;32(6):1076-1081. doi:10.1001/archotol.1940.00660021084009

An angioendothelioma is an angiomatous tumor composed of blood vessels in early stages of formation and possessing low grade malignancy.1 Golgi is credited as being the first to use the term endothelioma, in 1869, and Maurer2 in 1879 described 2 cases of slowly growing malignant tumors composed of ingrowth from endothelial lining of blood vessels, which he called angiosarcoma. Franke3 a year later described a tumor of tissue and blood spaces lined with endothelial cells, which he preferred to call endothelioma rather than sarcoma. Borst4 stated that angioendothelioma is clinically rather benign, although it does cause local destruction of tissue and recurs when removed. According to Geschickter and Keasbey,5 when active proliferation occurs in capillary angiomas in which masses of endothelial cells are seen about the vascular channels, a subvariety of these tumors, angioblastic hemangioma, is created. They are sometimes called hemangioendothelioma and are difficult at times to distinguish microscopically

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