John Abercrombie discovered the first thrombosis of a cavernous sinus to be reported. He made the finding during an autopsy, and it was reported by Duncan1 in 1821. Clinical reports were also made in 1839, by Vigla (cited by MacGuire2). MacGuire2 stated that in 1923 not many fatal cases had been reviewed in the literature and that the seriousness of the condition was not generally appreciated at that time. Before 1923 only two contributions of consequence could be found, one of which was by Bullock.3 Bullock ligated and divided both facial veins before treating a serious carbuncle involving the upper lip, from which the infection had spread, causing the eyelids to become red and swollen shut. This appears to be the first case in this country in which the patient was saved by ligation of the facial veins.
Among the many causes of thrombosis of a cavernous sinus are
PACE E. THROMBOSIS OF THE CAVERNOUS SINUS. Arch Otolaryngol. 1941;33(2):216–230. doi:10.1001/archotol.1941.00660030219006
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.