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February 1941


Arch Otolaryngol. 1941;33(2):325-330. doi:10.1001/archotol.1941.00660030328018

Labyrinthitis and Meningitis with Recovery: A Case Report. DR. WILLIAM E. GROVE and DR. GERHARD D. STRAUS. A girl 7 years of age suffering from labyrinthogenic meningitis was cured by radical mastoidectomy and massive doses of sulfanilamide without surgical treatment of the labyrinth. In the first twenty-four hours following operation 140 grains (8.4 Gm.) of sulfanilamide was given; this was decreased to 60 grains (3.9 Gm.) daily for the next four days, then to 40 grains (2.6 Gm.) daily for eighteen days. After the first twenty-four hours the concentration of sulfanilamide in the blood was 23.8 mg. per hundred cubic centimeters and was maintained thereafter at from 12 to 16 mg. Two transfusions of citrated blood were given postoperatively. By the eighth day the spinal fluid cell count had decreased from 3,900 to 31, and it then gradually returned to the normal.

Physical examination eight months after operation showed the

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