The upper respiratory tract presents an ideal absorptive surface for the application of antigenic material. Krishnamurthy1 found that the absorption of bacteria in the tracheal mucosa of immunized animals takes place at a slower rate than in normal animals. Maugeri2 studied the penetration of the tracheal mucosa by anthrax bacilli, Bacillus subtilis, sarcinas and staphylococci. The organisms were found in the epithelium within fifteen minutes, and after six hours they had disappeared entirely. Nasal immunization has the advantage over the ordinary methods of immunization in that a lesion is not produced by the inoculation. Although nasal immunization has been tried over a period of years (Bailey,3 Bull and McKee,4 Sabin,5 Sewall,6 Walsh and Cannon7 and others), it has had only a limited practical application. The main reason for the limited use of this procedure has been the possible danger of causing pneumonia. In fact, in a number of cases observed,
WEISS E. SPREADING OF VACCINE IN NASAL VACCINATION. Arch Otolaryngol. 1941;33(4):623–630. doi:10.1001/archotol.1941.00660030631011
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