During the past decade Coutard's1 method of protracted fractional irradiation has made it possible to treat neoplasms of the larynx, without serious or fatal consequences, with doses many times those given in earlier years. However, because Coutard's method is a principle rather than a well defined technic and is undergoing, as experience dictates, many adaptations, the question of surgical procedure versus irradiation in the treatment of laryngeal neoplasms remains at present sub judice. The number of patients treated by radiation and followed for five to ten years is small, and opinion on the effect of roentgen treatment is therefore based on evidence insufficient in many respects. Despite the fact that it is now possible to give sufficient roentgen radiation, following the principle of Coutard, to cause disappearance and clinical cure of carcinoma of the larynx in many cases, few studies of radiation effects on laryngeal tissues appear in the
BRIGHTON GR, ALTMANN F, HAGAN C. REACTIONS OF LARYNGEAL TISSUES FOLLOWING EXTENDED FRACTIONAL ROENTGEN IRRADIATION. Arch Otolaryngol. 1941;33(4):631–658. doi:10.1001/archotol.1941.00660030639012
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