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Article
May 1941

CONCENTRATION OF MENTHOL IN THE SMOKE FROM MENTHOLATED CIGARETS: A STUDY OF LOCAL AND SYSTEMIC EFFECTS

Author Affiliations

NEW HAVEN, CONN.
From the Laboratory of Applied Physiology, Yale University.

Arch Otolaryngol. 1941;33(5):711-716. doi:10.1001/archotol.1941.00660030721004
Abstract

Most of the cigarets on the market contain, in addition to tobacco, small amounts of other ingredients intended to improve the physical character or the flavor of the tobacco. In occasional instances a distinct flavor is imparted by one or another of these ingredients; this occurs with cigarets containing menthol. The question has been raised whether the daily inhalation of volatilized menthol in the amount present in such cigarets may be injurious, either from local or from systemic effects. The present study was undertaken to answer this question.

The irritation of the mucosa caused by nasal sprays containing menthol has been studied by Fox.1 When 5 per cent menthol was applied daily for nine months, there was definite injury to the mucosa; there was some evidence of ill effects even with concentrations as low as 1 per cent. The statement has been made, but with no evidence given to support

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