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June 1941


Author Affiliations

From the Division of Experimental Medicine and the Department of Medicine, University of Oregon Medical School.

Arch Otolaryngol. 1941;33(6):961-968. doi:10.1001/archotol.1941.00660030972004

Chemotherapy will aid the otorhinolaryngologist in contributing to the health and happiness of patients with infections of the middle ear, mastoid, nasal accessory sinuses, nasopharynx and larynx. It will possibly save the lives of patients with complications such as osteomyelitis of the cranial bones, meningitis, lateral sinus thrombosis and brain abscess.

Most of the suggestions given here for the chemotherapy of infections are based on experiments made by the marrow culture method.1 This method permits controlled quantitative study in the presence of living human cells of the relative effectiveness of different therapeutic agents against many types of micro-organisms and comparison with a control which is untreated. It has great advantages over clinical investigation and animal experimentation.2 The observations made on chemotherapy by this method have been confirmed by subsequent clinical studies except in those cases which are too recent for clinical studies to have been completed. Other suggestions given here

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