In a previous paper1 were reported the results of experiments with three methods of producing fistulas in bone, viz. (1) with a sharp chisel, (2) a burnishing burr and (3) a burnishing burr followed by electrocoagulation. After two months and two days there was evidence of bone formation where each of the three methods had been used, but where the sharp chisel had been employed, the osteogenesis was least marked
The present research was undertaken with the thought that through chemical means it might be possible to inhibit osteogenesis.
It is known that copper, even in minute amounts, inactivates vitamin C by catalytic oxidation. Vitamin C is necessary to the gelling of collagen in the formation of bone matrix; therefore in the absence of vitamin C bone cannot form.
As in our previous work, the fistulas were made in the craniums of white rabbits. Three experiments were undertaken; in all
GUGGENHEIM P, GUGGENHEIM L. A NEW METHOD FOR INHIBITING OSTEOGENESIS IN ARTIFICIAL BONE FISTULAS: Preliminary Report. Arch Otolaryngol. 1941;34(2):356–357. doi:https://doi.org/10.1001/archotol.1941.00660040382014
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