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Article
November 1941

GRANULOMATOUS ULCER OF THE NOSE AND FACE: OF UNKNOWN CAUSE, USUALLY PROGRESSIVE, GANGRENOUS AND FATAL

Author Affiliations

BOSTON
From the Department of Otorhinolaryngology, the Lahey Clinic.

Arch Otolaryngol. 1941;34(5):865-879. doi:10.1001/archotol.1941.00660040935001
Abstract

This presentation will consist of a short review of the literature on the subject described by the title and a report of 4 cases in which treatment was given by personal acquaintances or by me. A fifth case is mentioned, which closely resembles those which terminated fatally. It is hoped that this study will stimulate interest in the subject and possibly lead to further research in this country concerning the cause of the disease.

REVIEW OF THE LITERATURE  Fatal granulomatous ulcerations of the nose and face have been described under various titles. In 1896 McBride1 described a "case of rapid destruction of the nose and face." The following year Jones2 described a case of "esthiomenic menstrual ulcer of the nose." In 1906 Fordyce3 presented "a case of undetermined tropical ulcer involving the nose, pharynx and larynx, with histological findings." In 1914 Nabarro4 discussed "an obscure case of ulceration of the

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