Deposits of pigment in the internal ear have been observed in mammals by a number of pathologists. Certain questions have arisen relative to the origin of the pigment, but its presence has been accepted as a commonplace fact without pathologic significance. In a study of 28 human membranous labyrinths, Wolff1 reviewed the reports in the literature, including those of Corti,2 Voltolini,3 Lucae,4 Waldeyer,5 Retzius,6 Alexander,7 Siebenmann,8 Ranvier,9 Kolmer10 and Maximow.11 It is clear that she was impressed by Kolmer's statement that the amount of pigmentation in the region of the labyrinth is dependent on the general pigmentation of the animal and that therefore labyrinthine coloration is lacking in albinos. Wolff therefore questioned all reports in the literature in which pigment was stated to be absent and generally concluded that the animals used as subjects must have been white ones.
A. A. Gray12 stated that it would be interesting to know
LEDERER FL. MELANOSIS OF THE INTERNAL EAR. Arch Otolaryngol. 1942;35(2):267–280. doi:10.1001/archotol.1942.00670010269005
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