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February 1942


Arch Otolaryngol. 1942;35(2):281-285. doi:10.1001/archotol.1942.00670010283006

Chemotherapy has become an important means for the effective combating of infections, which previously depended on less specific agents. Sulfanilamide, which was one of the first drugs synthesized, has been used with success against otogenic infections. Many operations for acute mastoiditis have been avoided by early use of this drug.

Investigative studies have shown that under certain in vitro conditions sulfanilamide is effective in its bacteriostatic property in a dilution of 1:10,000. In higher concentrations, however, the bactericidal and bacteriostatic influences may be augmented considerably. Clinically, a blood concentration of free sulfanilamide up to 10 to 20 mg. per hundred cubic centimeters can be obtained. The solubility of sulfanilamide at body temperature is about 0.8 per cent. It has been demonstrated that many substances, including peptone, may interfere with the action of sulfanilamide on micro-organisms.

In an active focus of infection to which the blood supply is impaired, because of

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