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April 1942


Arch Otolaryngol. 1942;35(4):623-630. doi:10.1001/archotol.1942.00670010628010

In every case of sinusitis, as of all other diseases, it is necessary for the physician to determine whether he may safely entrust recovery to Nature alone or whether he must come to her aid with the resources of his art. He therefore must understand, to the extent that present knowledge permits, the normal operations of the human body when infected with pathogenic organisms.

Whenever these organisms gain entrance into the tissues, their toxic products stimulate the tissues to manufacture antibodies for the purpose of destroying the microbes and neutralizing their toxins. Should the bacteria overcome this natural immunity, the subsequent arrest of their growth comes not from exaltation of the bactericidal powers of the local tissues but from antibacterial substances elaborated in the uninfected tissue.1 The scientific exploitation of this protective mechanism for therapeutic uses is the essential feature of the treatment of bacterial disease by vaccines.2 Inoculating the

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