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June 1942


Arch Otolaryngol. 1942;35(6):988-997. doi:10.1001/archotol.1942.00670010996017

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Clinical Aspects of Chemotherapy.Dr. Walter Scriver.  It is interesting that such an advantage as is given by sulfanilamide and its derivatives came out of international research. Compounds of this group were first used in Germany in experiments with mice, and the experimenter, Gerhard Domagk, was awarded a Nobel prize, which his government would not allow him to accept. Then they were used in France and next in England, where they were first applied clinically in the treatment of puerperal septicemia and proved extremely valuable. Next they came to North America and were investigated particularly at Johns Hopkins Hospital, Baltimore.It is also interesting to hear about the many individual drugs in this broad group. Sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine), which caused so much furor, was synthesized in England. Sulfanilamide was rather unfortunately prepared in an elixir form by one manufacturer in the United States, and this elixir caused a number of deaths.

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