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October 1942

ACCIDENTAL VACCINIAL INFECTION OF THE NOSE: Review of the Literature and Report of a Case of Laboratory Infection

Author Affiliations

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Otolaryngol. 1942;36(4):556-559. doi:10.1001/archotol.1942.03760040110011

Accidental nasal infections with vaccinia have undoubtedly occurred in the United States, but the case to be reported seems to be the first in the American literature, while 16 cases have been found in the foreign literature. The review of such reports is of interest because of the difficulty in diagnosis of vaccinial lesions in the nose which do not show the typical papulopustular appearance. It seems of particular interest during the present war emergency, which necessitates wholesale vaccination of many persons.

Kronenberg1 reported the first case in 1896. A boy 8 years old had an old nasal eczema, which was associated with some itching. He acquired a superimposed infection after his brother had been vaccinated. Material from the nasal lesion produced a typical vaccinial lesion in the father's arm. Sadler2 reported the case of infection of the mucosa of the nasal septum in a woman who had

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