It takes only a cursory review of the literature to reveal that not a large amount of research has been done on keratosis of the larynx. Possibly the reason for this is the scarcity of material and the ease with which most cases have been handled by removal of the lesion, together with its underlying structure.
The essential details of the observations that have been made may be summarized as follows: 1. Keratosis of the larynx is a precancerous disease. 2. The process is a localized cornification of the epithelium without invasion of the submucosa. 3 (to me most important). A chronic inflammatory process is diffused throughout the mucus membrane of the larynx, with localized areas of intensity about the base of the individual lesions. 4. The cause has not yet been determined.
Jackson and Jackson1 made the statement that so far in no case had a malignant process
GRAHAM HB. KERATOSIS OF THE LARYNX. Arch Otolaryngol. 1942;36(5):735–739. doi:10.1001/archotol.1942.03760050127013
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