Since the advent of the sulfonamide compounds there have been continual trial and error attempts to apply them to almost every kind of ailment. Local application has received much attention, and of late a much heralded article1 on the use of sulfathiazole in the nose as a treatment and cure of chronic sinusitis has made me wonder just what effect it has on the nasal mucous membrane.
It has been proposed that a spray or instillation in the nose of a 5 per cent solution of sodium sulfathiazole (sodium salt of 2-[paraaminobenzenesulfonamido]-thiazole) three times a day for a number of days in one suffering from chronic sinusitis would cure the condition. This was based without presentation of experimental data; so there was no way to determine the effect of the drug on the mucous membrane. Then an article2 came out telling of the very corrosive effect on the