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Article
February 1943

EFFECT OF THE NEWER SULFANILAMIDE DERIVATIVES ON THE NASAL MUCOSA OF RABBITSPRELIMINARY REPORT

Arch Otolaryngol. 1943;37(2):209-218. doi:10.1001/archotol.1943.00670030218006
Abstract

In the last five years sulfanilamide and its derivatives have revolutionized the treatment of many serious bacterial infections. The spectacular results obtained when these drugs were administered internally prompted many clinicians to apply them locally. This allows a greater concentration at the site of infection. Favorable results reported in the healing of infected wounds,1 compound fractures2 and many other conditions3 led my associates and me to become interested in investigating the value of the drugs for the local treatment of infections of the nose and paranasal sinuses.

For the past eighteen months we have used a saturated (0.8 per cent) solution of sulfanilamide4 for the treatment of sinusitis, the solution being introduced into the infected sinuses by the Proetz displacement method. Some apparent success was noted, but it was thought that a stronger solution might be more efficacious, were it available.

Recently solutions of greater strength have been made possible

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