Vaughan and Derbes1 investigated the relationship between infection and allergy, using 250 patients who were definitely allergic in one way or another and 250 nonallergic patients. They concluded that no significant difference was found in the incidence of acute infectious diseases in allergic and nonallergic persons. This brings up the question of the etiologic and the predisposing factors of "allergy."Urbach2 presents various etiologic factors and draws his material from the most important physiologic experiments. 1. Experimental anaphylaxis may be induced at will in animal species with certain antigens. Atopic hypersensitiveness cannot be induced, even by artificial contact, in persons not subject to the atopic hereditary influence (atopy being defined as a type of hypersensitiveness peculiar to man which is subject to hereditary influence). 2. Experimental anaphylaxis follows a previous, intentional exposure to a given antigen. Human "atophy," on the other hand, often seems to occur without any demonstrable
MACQUIDDY FL. REVIEW OF ALLERGY FOR 1941. Arch Otolaryngol. 1943;37(3):440–452. doi:10.1001/archotol.1943.00670030450016
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