A study of acute pharyngeal infections treated by the topical application of sulfathiazole powder in the otolaryngologic dispensary of St. Luke's Hospital is presented here. Sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) is the thiazole analogue of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and was first reported on by Fosbinder and Walker1 and by Lott and Bergeim.2 These authors described the methods of preparation and their experiments with these drugs against streptococcic and pneumococcic infections in mice. The original work on the physical and chemical characteristics of sulfathiazole and its salt was done at that time, and tests for the estimation of the drug in the body were described.
Van Dyke and his co-workers3 showed the rapid metabolism of this drug in the body. Sulfathiazole was proved to be more rapidly absorbed than other sulfanilamide derivatives, the concentration in the blood reaching its highest level in one to three hours after ingestion of the drug. Moreover, it disappeared and
FREEMAN MS. LOCAL USE OF SULFATHIAZOLE POWDER FOR ACUTE PHARYNGEAL INFECTIONS. Arch Otolaryngol. 1943;37(4):496–501. doi:10.1001/archotol.1943.00670030508003
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