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April 1943


Arch Otolaryngol. 1943;37(4):601-607. doi:10.1001/archotol.1943.00670030613014

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Specific in Vitro Action of Sulfonamide Compounds on Pathogenic Organisms.Dr. Milan Novak (by invitation).  In sufficiently high concentration, such as those used in local therapy, all the common sulfonamide compounds are bacteriostatic for all species of bacteria. Specificity of drug action against a given bacterium is demonstrated only in lower concentrations, such as those obtained in systemic therapy. The choice of a sulfonamide compound for systemic therapy should be based primarily on specificity; for local treatment the accessibility of the wound and the solubility of the drug should receive the most consideration. Specificity of action as demonstrated in the test tube cannot be used as a sole criterion for selection of a sulfonamide derivative for a given condition, since toxicity, cost and relative solubility are equally important to consider.

Pharmacologic Development of the Sulfonamide Compounds and Their Action.Dr. Frank T. Maher (by invitation).  Rational progress in chemotherapy with

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