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June 1943


Arch Otolaryngol. 1943;37(6):831-834. doi:10.1001/archotol.1943.00670030846010

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During experimental research in blood coagulation Steinberg and Brown, of the Kensington Hospital for Women of Philadelphia, found that the intravenous or intramuscular injection of oxalic acid in experimental animals produced a rapid fall in the blood coagulation time of these animals. Thus, the results which they observed were diametrically opposed to those obtained in vitro. Oxalic acid is a chemical found in abundance in nature and has long been known to be toxic when administered in large doses. Solomon stated that the lowest recorded fatal dose was 5 Gm. and the lowest toxic dose 10 grains (0.65 Gm.), the latter being about the amount found in 1 pound (453 Gm.) of rhubarb greens. Oxalic acid is deemed to be rather inert in the body and appears to be excreted by the kidneys. Ingestion of large amounts of this substance appears to cause death by clogging the renal mechanism.


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