Hypertelorism is a congenital abnormality the diagnosis of which is made evident by the facial appearance. The person so afflicted has an animal-like countenance. It may be defined as a craniofacial dysostosis resulting from overgrowth and early ossification of the lesser wings of the sphenoid bone leading to separation of the orbits, large interpupillary distance and excessive width at the base of the nose with distortion of the tip. In most cases there is a divergent squint.
The earliest description of this condition was published by Giovanni Battista, who called attention to the facial resemblance of his patient to the bovine.
Greig1 introduced the term "ocular hypertelorism" because of the prominent orbital abnormality. He also described the cause after autopsy in a case in which he found enormous enlargement of the lesser wings of the sphenoid bone. Bojlen and Brems2 in subsequent autopsies confirmed the anatomic observations of Greig.
BERKOVE AB. HYPERTELORISM. Arch Otolaryngol. 1943;38(6):587–589. doi:10.1001/archotol.1943.00670040610006
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