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December 1943


Author Affiliations


Arch Otolaryngol. 1943;38(6):597-626. doi:10.1001/archotol.1943.00670040620009

TECHNICAL STUDIES  Anesthetic Agents.—The employment of the newer anesthetic agents in the field of peroral endoscopic procedures often brings to light certain untoward effects which were not discovered during the preliminary experimental studies.In a report based on a review of the literature as well as on their personal experiences with tetracaine (marketed as pontocaine hydrochloride), Thomas and Fenton1 found that severe reactions had followed its employment in 7 cases. These included three deaths. Four of the reactions resulted from its use in preparation for or during bronchoscopic examination, and three followed its use in preparation for gastroscopic examination. Their experiences substantiated those of other workers regarding the character of the reactions and the correlation of symptoms in certain groups of persons, notably allergic patients, and also in persons without a definite history of allergy, such as emaciated patients.Patch tests with tetracaine and cocaine were made on a number

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