Prior to the era of chemotherapy, true cases of thrombosis of the cavernous sinuses were invariably fatal. None that I know was ever reported with cure. Medical treatment was of no avail. Surgical procedures, such as ligation of the facial vein, met with similar results. Since the introduction of sulfonamide compounds, however, a number of cases of thrombosis of the cavernous sinus have been reported with cure.1
Before presenting my case I shall review briefly the etiology and trace the course of the thrombus from the source of infection to the cavernous sinus. Infection originates from anterior, intranasal, posterior and inferior foci. In this case the port of entrance was anterior: a furuncle on the bridge of the nose. The septic thrombus spread to the angular, to the supraorbital, to the supratrochlear and to the ophthalmic vein, emptying into the cavernous sinus. There it extended to the opposite side, affecting
WOLF JW. THROMBOSIS OF THE CAVERNOUS SINUS WITH HEMOLYTIC STREPTOCOCCIC BACTEREMIA: TREATMENT BY INTRAVENOUS INJECTION OF SULFADIAZINE AND PENICILLIN, WITH RECOVERY. Arch Otolaryngol. 1944;40(1):33–37. doi:10.1001/archotol.1944.00680020045004
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