When von Jeney and Törö1 added ascorbic acid to the nutrient medium of a culture of fibroblasts in vitro and observed a marked increase in the number of collagen fibrils, the basis was laid for an advance in the local treatment of wounds. Since the repair and the tensile strength of wounds in soft tissues are direct functions of the proliferation of fibroblasts and the formation of collagen, it is evident that vitamin C plays an important role in the phenomenon of wound healing. Saitta2 reported delayed healing of exposed surface wounds in guinea pigs that had been kept on a vitamin C—deficient diet for more than fifteen days. On the other hand, when a vitamin C–containing extract was applied directly to the wound, the time of healing was appreciably diminished, regardless of whether the animals were maintained on a normal or a scorbutic dietary regimen. He determined the rate
RUSKIN SL. VITAMIN C—SULFONAMIDE COMPOUNDS IN THE HEALING OF WOUNDS: THE USE OF SULFANILAMIDE ASCORBATE IN THE TREATMENT OF CHRONIC SUPPURATION OF THE WOUND AFTER RADICAL MASTOIDECTOMY. Arch Otolaryngol. 1944;40(2):115–NP. doi:10.1001/archotol.1944.00680020147005
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