The local use of sulfonamide drugs in the management of infected wounds is now well established in both civilian and military surgical practice. Perhaps the most conspicuous application has been in the treatment of compound fractures, and since these are among the most frequent wounds of battle, the local application of sulfonamide compounds in such wounds is now common. Sulfonamide compounds have also been used extensively, and with equally satisfactory effects, in infected abdominal wounds. Livingston1 apparently was the first to report on the use of sulfanilamide crystals in the cavity of the mastoid process after mastoidectomy. Since his report, the local use of sulfonamide drugs after mastoidectomy has become widespread, and numerous articles have appeared in the literature. These are essentially in agreement that the procedure when combined with good surgical technic has great value, although there are some minor differences of opinion regarding closure of the wound and