The literature is diffusely infiltrated with suggestions concerning the therapy of acute otitis media. The subject is a time-honored one and justifiably so. Treatment of the condition has radically changed during the past few years, since the advent of the various sulfonamide compounds. The monumental work of Domagk, who demonstrated that prontosil1 exerted a selective action on streptococcic infections in mice, cannot be minimized.2
... The literature is replete with clinical material which adds little to the sum of knowledge, and one is puzzled even to find the raison d'être for some of the case reports, since they settle no questions and too often only reiterate accepted facts and customary procedures.
Almost phenomenal results in all cases of acute and even subacute otitis media have been obtained with adequate and carefully supervised use of sulfonamide compounds (see the accompanying table).
It is obvious that the patient
RIGG JP. RATIONAL THERAPY IN ACUTE OTITIS MEDIA. Arch Otolaryngol. 1945;41(2):137–139. doi:10.1001/archotol.1945.00680030162006
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