The bacteriostatic effectiveness of the sulfonamide drugs is well established. Although the mechanism by which these drugs produce their inhibitory influence is not completely understood, numerous clinical and laboratory studies have demonstrated that the drugs are useful in preventing and controlling certain types of infection if they are maintained at the wound site in sufficient concentration.
Early studies were concerned with building up and maintaining blood levels of the drugs by oral administration, but more recent work has shown that the direct local application of the drugs in accessible areas is highly efficient.
Effective topical application of the drugs to diseased or injured oropharyngeal tissues has been difficult, mainly because mechanical factors prevented the maintenance of a satisfactory concentration of the drug. The smooth oral mucosa is continually washed by saliva and does not lend itself favorably to treatment by powders, ointments or solutions. Beneficial results from the local application
FOX N, KESEL RG, NEARY ER, HERBINE RH. EFFECT OF SULFATHIAZOLE IN CHEWING GUM IN CERTAIN OROPHARYNGEAL INFECTIONSA PRELIMINARY REPORT. Arch Otolaryngol. 1945;41(4):278–283. doi:10.1001/archotol.1945.00680030305005
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