The modern miracle of therapy with sulfonamide compounds already is taken for granted. There are some writers who condemn the indiscriminate use of the drugs of this group; on the other hand new uses are described frequently. How necessary and how dangerous are these compounds? Toxicity and sensitization are not negligible hazards, and prolonged or repeated application is not required to develop them. Furthermore, as Schenck1 has warned, unless there is comprehension of the underlying pathologic process, the drug may merely mask symptoms while the infection progresses to disaster.The increasing topical use of sulfonamide compounds is predicated on the advantage of greater concentration at the site of infection and the lesser likelihood of toxic effects. Local application is to be preferred to systemic whenever equally good results may be expected. Osgood2 expressed the opinion that one should weigh the risk of the disease and should know that the
ORNSTON DG. USE OF MICROCRYSTALS OF SULFATHIAZOLE IN OTOLARYNGOLOGIC PRACTICE. Arch Otolaryngol. 1945;41(5):337–342. doi:10.1001/archotol.1945.00680030366005
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