For a long time it has been known that the cavernous sinus is vulnerable to infections of the face and the nose. Thrombosis of the cavernous sinus was usually considered a fatal disease until the advent of sulfonamide compounds in therapy. Recovery was rare.
Grove1 after an extensive review of the literature on the subject in 1936 made the following statements: "In the septic types in which the thrombosis or thrombophlebitis reaches the cavernous sinus by way of the afferent vessels the mortality is practically 100 per cent. . . . When the thrombus originates from a septic source, the focus should be vigorously treated. The cavernous sinus itself should be let alone."
Staphylococcus albus and Staphylococcus aureus are the organisms usually responsible for fatal thrombosis. Thrombosis of the cavernous sinus can occur at any age but the youngest patient with recovery whose case I have found reported (by Cohen
WHITE JW. PENICILLIN THERAPY FOR THROMBOSIS OF THE CAVERNOUS SINUS IN A FOURTEEN MONTH OLD CHILD. Arch Otolaryngol. 1945;42(2):147–148. doi:10.1001/archotol.1945.00680040183010
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