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Article
November 1945

PENICILLIN THERAPY IN THE PRACTICE OF OTOLARYNGOLOGY

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES

Arch Otolaryngol. 1945;42(5):327-338. doi:10.1001/archotol.1945.00680040447002
Abstract

Penicillin therapy is of definite value in the treatment of many diseases of the ears, the nose and the throat. It is particularly applicable in this field, because the great preponderance of pathogenic organisms encountered in the practice of otolaryngology are of the penicillin-sensitive group.

The penicillin-sensitive and the insensitive organisms commonly encountered by otolaryngologists are as follows according to Herrell, Nichols and Heilman.1

  • Penicillin-Sensitive Group

    • Diplococcus pneumoniae .......... Gram positive

    • Streptococcus .................... Gram positive

    • Staphylococcus ................... Gram positive

    • Neisseria intracellularis (Neisseria meningitidis) ................. Gram negative

    • Corynebacterium diphtheriae ...... Gram positive

  • Penicillin-Insensitive Group

    • Bacterium Friedländeri (Klebsiella pneumoniae) (encapsulated) .... Gram negative

    • Pseudomonas pyocanea (Pseudomonas aeruginosa) ............... Gram negative

    • Mycobacterium tuberculosis ....... Gram positive

    • Haemophilus influenzae ........... Gram negative

There are many cases encountered in the practice of otolaryngology in which both penicillin and the more easily administered and less costly sulfonamide compounds are effective. In such cases it has

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