XANTHOMA of the skin and of the tendons has been known for a long time. Xanthoma of the eyelids is seen as raised yellow patches and is termed "xanthelasma palpebrarum." Similar plaques are occasionally seen in the buccal mucosa. The real nature of xanthoma was not understood until about two decades ago.
Credit is due the dermatologists who have made histologic studies of xanthoma of the skin and thus have paved the way toward the recognition of similar lesions in the internal organs, the skull and the paranasal sinuses. An extremely interesting literature on various phases of the subject has been published, but the limited scope of this paper permits only brief reference to it.
The otologist's interest in xanthomatosis lies in the fact that the temporal bone becomes affected in a great number of the cases of xanthoma of the skull. Besides the lesions in the skull, the reported
M. A. GLATT. XANTHOMA OR LIPOID GRANULOMA OF THE TEMPORAL BONE (HAND-CHRISTIAN-SCHÜLLER SYNDROME). Arch Otolaryngol. 1946;43(2):110–121. doi:10.1001/archotol.1946.00680050122003