THE case to be reported is of particular interest because of the following observations:
Porosity of the anterior and posterior walls of the left frontal sinus disappeared and acute pansinusitis of the left side cleared up completely except for a cyst in the left antrum when penicillin was injected intramuscularly in a dosage of 100,000 to 200,000 units per day for three weeks.
Treatment for an infection of a flat bone, including the frontal bone, is adequate when 200,000 units of penicillin is injected daily for three weeks,1 so far as intramuscular injection of penicillin may aid in lessening the need for surgical intervention in this condition. In other words, an adequate trial of penicillin for the prevention or the treatment of osteomyelitis of a flat bone has been made when 200,000 units has been injected intramuscularly daily for three weeks. Of course, such a trial may be unsuccessful, with
WEILLE FL. MAXILLARY SINUSITIS AND ETHMOIDITIS OF THE RIGHT SIDE DEVELOPING DURING INTRAMUSCULAR INJECTION OF PENICILLIN FOR PANSINUSITIS OF THE LEFT SIDE. Arch Otolaryngol. 1946;43(2):136–140. doi:10.1001/archotol.1946.00680050148006
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