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THE TREATMENT of infections of the middle ear frequently presents a problem both to the general practitioner and to the specialist. Because of the prevalence of suppurative otitis media and its wide distribution, any treatment which might safely result in a cure of the disease in the shortest possible time is worthy of trial. The treatment of aural infections with ear drops has long been standard. In recent years the use of sulfonamide drugs has been widespread in an attempt to shorten the duration of the disease. Opinions as to the efficacy of this treatment have varied. It has been praised as a short cure for suppurative otitis media and has been decried as a masker of complications of this disease. The use of sulfonamide compounds is always accompanied by the possible development of specific sensitivity, manifested by cutaneous eruptions or blood dyscrasias. There is also the possibility of renal
LOEB WJ. PENICILLIN EAR DROPS IN THE TREATMENT OF SUPPURATIVE OTITIS MEDIA. Arch Otolaryngol. 1946;43(6):586–592. doi:10.1001/archotol.1946.00680050612004
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