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Article
June 1946

EVALUATION OF BENADRYL AS A THERAPEUTIC AGENT FOR VASOMOTOR AND ALLERGIC RHINITIS

Arch Otolaryngol. 1946;43(6):597-604. doi:10.1001/archotol.1946.00680050623006
Abstract

THE ideal drug has not been found which will alleviate the uncomfortableness of the nasal congestion associated with vasomotor and allergic rhinitis until the causative factors can be eliminated or permanently controlled by other measures. The local use of ephedrine or ephedrine-like preparations is of value but gives relief for short periods only. Many such drugs produce subsequent vasodilatation and nervousness if used too frequently, and they tend to lose their effectiveness if constantly used for long periods. Preparations belonging to this group must be used rather cautiously in hypertensive patients and patients with cardiac disease.

When persons seek advice for nasal congestion and its associated complaints, the rhinologist must attempt to give them temporary relief while the investigation to determine the etiologic factors proceeds. Since the investigation is often time-consuming, with laboratory studies, allergy studies and consultations, palliative measures are necessary until the rhinologist can definitely determine the proper

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