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October 1946


Arch Otolaryngol. 1946;44(4):385-391. doi:10.1001/archotol.1946.00680060406002

IS THE basic fault in Ménière's syndrome a dysfunction of the capillaries? It is proposed in this paper to examine the evidence which has accumulated in recent years regarding the pathogenesis of this condition, in order to see how far such a proposition can be justified.

I. THE HISTOLOGIC EVIDENCE  Ménière's disease not being of itself lethal, understanding of it has until recently been greatly handicapped for want of postmortem material. But with the advent of operation in treatment, a few cases of postoperative death have occurred and come to autopsy and a few other actual or analogous cases have been found, so that this gap in knowledge is in process of being filled.In 1938 Hallpike and Cairns1 made the first report on the histologic appearances of the temporal bones in typical cases of Ménière's syndrome (describing two ears), and since then the ears in several other charecteristic cases