THE WIDE acceptance of a rationalized form of nasal and sinal therapy can be established only in the event of a clear understanding of the manner in which drugs work. This understanding can be assisted materially by studying the effect of nasal preparations on (1) nasal or sinal mucosa, (2) ciliary motility and (3) the hydrogen ion concentration of the nasal secretions and by noting the production or the absence of local and systemic side effects. Nontoxic nasal medicaments that are compatible with ciliary motility, that do not vary greatly in their hydrogen ion concentration from that of normal nasal secretions (pH 5.5 to 6.5) and that are nontraumatizing to the mucous membranes are most useful in the treatment of the nose and the nasal sinuses—for they function on a rational, physiologic basis.1a
Although it may be difficult for physicians to believe in retrospect that they were ever deluded, each
FABRICANT ND, HOLLENDER AR, ANDERSON HW. EFFECT OF VARIOUS SOLUTIONS OF PENICILLIN SODIUM AND PENICILLIN CALCIUM ON THE RESPIRATORY NASAL MUCOSA OF RABBITS. Arch Otolaryngol. 1947;46(1):36–39. doi:10.1001/archotol.1947.00690020043002
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