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Article
February 1948

PENICILLIN AND STREPTOMYCIN AEROSOL IN THE TREATMENT OF PULMONARY DISEASE

Arch Otolaryngol. 1948;47(2):138-148. doi:10.1001/archotol.1948.00690030147005
Abstract

IN MAY 19.45 we1 reported our preliminary experience with penicillin inhalation therapy. The results obtained in 22 cases of pulmonary disease were given, and conclusions were reached that while penicillin aerosol was helpful against bronchiectasis, another antibiotic was necessary to eliminate the gram-negative, penicillin-resistant bacteria. We had tried streptomycin aerosol in case 8 of our preliminary report, with encouraging results, but we did not mention the name of the antibiotic as the manufacturer asked that it be withheld, fearing too great a demand for the substance at that time. The present report concerns a series of 10 patients treated with both penicillin and streptomycin. In addition, the results of the use of penicillin inhalations as observed in 111 patients encountered by the department of anesthesia in the routine management of inhalation therapy are given. The question of blood levels is also considered.

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