IN 1908 VEROCAY1 first described the histologic appearance of a highly differentiated tumor which resembled the nerve sheath within which it was commonly found, and in 1910 he gave the term "neurinoma" to this type of tumor. A review of the literature reveals such names applied to this tumor as "neuroma," "neurinoma," "palisading neurinoma," "neurofibroma," "solitary neurofibroma," "perineurial fibroblastoma," "fibroma of nerves," "peripheral glioma," "schwannoma," "gliofibroblastoma" and "lemmoma." This variation in terminology is evidence of the confusion which has existed because of uncertainty as to the origin of tumors of this type.
There are two main trends of thought regarding the origin of these tumors. The branching, anastomosing processes resembling connective tissue, which give rise to fibrils and collagen and are a specific product of the fibroblasts, have suggested to Penfield2 that these tumors originate from the perineurial fibroblasts and are therefore mesodermal in origin. The early works of Bard,
THORNELL WC, GERMAIN WM. SOLITARY NEUROFIBROMA OF THE SUBMAXILLARY REGION. Arch Otolaryngol. 1948;47(3):333–335. doi:10.1001/archotol.1948.00690030353007
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