OTOSCLEROSIS (otospongiosis), being largely a disease of bone, one would suspect in this disorder, at least during its active phases, some disturbance of the blood serum calcium-phosphorus content or balance, and maybe of serum phosphatase activity, also. Many attempts have been made to correlate calcium-phosphorus variations with otosclerosis, but no generally accepted conclusions have been reached. No serious attempt has been made with respect to phosphatase activity. There are several reasons for the negative or unimpressive results. One is the fact that the examination is made so long after the onset or an active stage of the disease that abnormal levels of the components of the blood serum have had time to return to near normal by the time the tests are made. Another reason may be that the so-called normal ranges for calcium and phosphorus values permit such large excursions between the normal extremes that in many people really
FOWLER EP. CALCIUM AND PHOSPHORUS, AND PHOSPHATASE ACTIVITY, IN OTOSCLEROSIS. Arch Otolaryngol. 1948;47(4):491–500. doi:10.1001/archotol.1948.00690030513013
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