THAT STREPTOMYCIN when administered in daily doses of about 2 Gm. over a period of from two to twelve weeks may cause considerable damage to the vestibular apparatus was reported by Brown and Hinshaw,1 Hinshaw, Feldman and Pfuetze2 and Marden3 in 1946. Fowler and Seligman4 made a similar report in 1947.
Brown and Hinshaw expressed doubt as to whether the lesion is in the vestibular end organ or in the brain. In 1947 Skoog5 proved that Ménière's syndrome can be produced in a guinea pig by a lesion of the brain stem. It must, therefore, be observed that Ménière's syndrome may follow a lesion of the vestibular nuclei in the brain stem as well as a lesion of the peripheral end organ.
An analysis of the vestibular data obtained on 3 patients treated with streptomycin at the Hospital of the University of Pennsylvania forms the basis of this paper
WINSTON J. VESTIBULAR FINDINGS BEFORE, DURING AND AFTER VESTIBULAR DAMAGE RESULTING FROM STREPTOMYCIN THERAPY. Arch Otolaryngol. 1948;47(6):746–751. doi:10.1001/archotol.1948.00690030773003
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