EVER SINCE the beginning of the present decade, attempts have been made to direct the interest of rhinologists to (1) the relation of the pH of nasal secretion in situ to applied nasal physiology and (2) to the importance of the pH factor in the field of nasal medication.1 Recognition of Fantus'2 dictum that a hydrogen ion concentration near that normal to the mucous membrane is a matter of even greater importance for applications to the mucous membranes than the matter of isotonicity has provided a firm foundation for rational, physiologic nasal medication.
So far as concerns the pH values of local medicaments, valid therapeutic conclusions have been drawn in a variety of clinical fields from measurements of the hydrogen ion levels of various secretions found in their original positions on underlying mucous membrane and tissue surfaces. Intranasal treatment by means of rational, physiologic nasal medication requires not only treatment
FABRICANT ND, PERLSTEIN MA. HYDROGEN ION CONCENTRATION OF NASAL SECRETION IN SITU IN INFANTS AND IN CHILDREN: With a Comment on pH Values in Pediatric Nasal Medication. Arch Otolaryngol. 1948;47(6):765–771. doi:10.1001/archotol.1948.00690030792005
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