IN A RECENT publication1 we described in detail a method for the quantitative evaluation of the irritation which cigaret smoke causes as judged by its edema-producing properties, based on gravimetric determination of the increase of the moisture content of the upper palpebral conjunctiva of a rabbit's eye that has been exposed to cigaret smoke. The method is briefly as follows:
A smoking machine of the type described by Bradford, Harlan and Hanmer,2 which draws a 35 cc. puff once a minute, is used. Three puffs, as a rule, are directed through a suitable cup placed over the widely opened eye of the morphinized rabbit. When one eye only of each rabbit is exposed, the other serving as a control, we name the technic procedure A. When both eyes of each rabbit are exposed, thereby permitting comparison of two cigarets on the same animal, the technic is called procedure B. In
HAAG HB, FINNEGAN JK, LARSON PS. CIGARET SMOKE IRRITATION: III. The Efficiency of Filters in Reducing Its Intensity. Arch Otolaryngol. 1948;48(1):41–46. doi:10.1001/archotol.1948.00690040048005
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