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November 1948

GAMMA GLOBULIN IN RELATION TO INFECTIONS OF THE RESPIRATORY TRACT: Experimental Study of the Local Use of Gamma Globulin in Treatment of the Common Cold

Author Affiliations

From the Department of Otology, Jefferson Medical College, and the Department of Pediatrics, University of Pennsylvania School of Medicine.

Arch Otolaryngol. 1948;48(5):527-535. doi:10.1001/archotol.1948.00690040540003

THAT a virus or viruses are responsible for the initiation of the common cold appears probable from all available data, although little is known of the nature of the causative agent or agents. Owing to this lack of knowledge, little progress has been made toward specific therapy of the common cold. However, specific antibodies against many viruses pathogenic for man, whether or not such viruses produce only a temporary or a permanent immunity in man, have been found in fairly constant amounts in the gamma globulin from large pools of human plasma.1 Thus, as in the case of epidemic influenza virus A or B,1 it is entirely possible that specific antibodies against the virus. or virus agents initiating the common cold may also be present in such gamma globulin. Whether antibodies are present in such constant amounts and whether they are virus neutralizing in their effect are entirely conjectural. If

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