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November 1948


Author Affiliations


Arch Otolaryngol. 1948;48(5):609-621. doi:10.1001/archotol.1948.00690040622008

THE LITERATURE on otitis media appearing in publications of 1947 is here reviewed under appropriate headings, for ease in comparisons. A number of very interesting articles appeared during this year, many of them deserving careful study in the original. Some articles are commented on under more than one heading. Editorial comments appear in brackets.

CHEMOTHERAPY AND BIOTHERAPY  Siirala1 continues his excellent experimental work and reports the results on experimental infections of the inner ear of guinea pigs. Virulent hemolytic streptococci were introduced directly into the cochlea in 18 guinea pigs. Alternate animals were given a sulfonamide (prontosil®) and the others used as controls. Animals were killed at short intervals and careful histologic sections made of the temporal bones. [Excellent illustrations accompany the article.] Study of the sections showed that the sulfonamide checked the spread of infection, especially at natural obstructions and narrow spaces.Streptomycin was used in 37 cases by