BECAUSE of its high incidence (over 10,000,000 in the white population of the United States1) and the meager knowledge as to its origin and control, otosclerosis is the number one mystery in otologic research. Any information suggesting a lead for solution should be carefully investigated. I invite attention at this time to some leads which seem to have been generally ignored.
For many years it has been known that certain sex-linked episodes frequently coincide with the onset or an increase of the deafness caused by otosclerosis, but no experimental explanation of the phenomena has been obtained or, in fact, even seriously attempted. In this article I am suggesting an explanation, which involves the sex hormones, and in particular the estrogens. The data and the argument are submitted tentatively and largely as suggestive for future research.
The bony skeleton of all animals depends on many complimentary and antagonistic factors for its
FOWLER EP. ESTROGEN, BONE METABOLISM AND OTOSCLEROSIS. Arch Otolaryngol. 1948;48(6):637–644. doi:10.1001/archotol.1948.00690040651001
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