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January 1949

MÉNIÈRE'S SYMPTOM COMPLEX: Its Relation to Chemistry; an Etiologic Study

Author Affiliations


Arch Otolaryngol. 1949;49(1):1-15. doi:10.1001/archotol.1949.03760070008001

THE CAUSE of Ménière's disease is unknown; so say the wise men of the medical profession. It has been variously ascribed to: disturbances of endocrine glands; infection; syphilis; low and high blood pressure; disturbances of the metabolism of salt, potassium, magnesium, iodine and calcium; deficiencies of certain vitamins (those responsible for spasm of blood vessels, as deficiency of thiamine, nicotinic acid or choline compounds); allergy; creatine-creatinine metabolism, and the action of the nondecarboxylated fraction of histidine-histamine. No one, so far as I know, has attempted to relate the disease to disturbances of nutrition and thus to body chemistry. This is the purpose in this paper.

VITAMIN DEFICIENCIES RELATED TO MÉNIÈRE'S DISEASE  Since the appearance of the first edition of the work of Williams and Spies1 on thiamine, in 1938, biologic and medical research have shown not only that degenerative changes occur in peripheral nerves but that, as Sure2