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February 1949

MÉNIÈRE'S SYNDROME: Observations on Vitamin Deficiency as the Causative Factor I. The Vestibular Disturbance

Arch Otolaryngol. 1949;49(2):151-174. doi:10.1001/archotol.1949.03760080029003

MÉNIÈRE'S syndrome may be regarded as consisting of two phases: (1) the acute, the attacks of vertigo or the vestibular disturbance; (2) the chronic, the deafness and tinnitus or the cochlear disturbance, which persists between the acute paroxysms. The present paper is concerned solely with the acute phase. The chronic phase will be dealt with in a subsequent communication.

In earlier papers1a, b it was reported that patients with Ménière's syndrome could be divided into two groups by determining the degree of response to an intradermal injection of histamine performed under standard conditions.2 Clinical experiments were described which showed that in the group which gives a small or negative response the symptoms are improved by vasodilator drugs and made worse by vasoconstrictor drugs, while in the group which gives a large or positive response the reverse is the case. These findings were interpreted as evidence for a vascular